In Silico Investigation into Cellular Mechanisms of Cardiac Alternans in Myocardial Ischemia
نویسندگان
چکیده
منابع مشابه
In Silico Investigation into Cellular Mechanisms of Cardiac Alternans in Myocardial Ischemia
Myocardial ischemia is associated with pathophysiological conditions such as hyperkalemia, acidosis, and hypoxia. These physiological disorders may lead to changes on the functions of ionic channels, which in turn form the basis for cardiac alternans. In this paper, we investigated the roles of hyperkalemia and calcium handling components played in the genesis of alternans in ischemia at the ce...
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In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes
RATIONALE Repolarization alternans (RA) are associated with arrhythmogenesis. Animal studies have revealed potential mechanisms, but human-focused studies are needed. RA generation and frequency dependence may be determined by cell-to-cell variability in protein expression, which is regulated by genetic and external factors. OBJECTIVE To characterize in vivo RA in human and to investigate in ...
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ژورنال
عنوان ژورنال: Computational and Mathematical Methods in Medicine
سال: 2016
ISSN: 1748-670X,1748-6718
DOI: 10.1155/2016/4310634